UV-spectrophotometry-assisted chemometric methods for simultaneous determination of ambroxol hydrochloride and doxofylline in pharmaceutical formulation
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چکیده
منابع مشابه
Simultaneous Determination of Ambroxol Hydrochloride, Cetirizine Hydrochloride, Methylparaben and Propylparaben in Liquid Pharmaceutical Formulation
Liquid preparations are particularly susceptible to microbial growth because of the nature of their ingredients. Such preparations are protected by the addition of preservatives that prevent the alteration and degradation of the product formulation [1]. The finished product release specifications should include an identification test and a content determination test with acceptance criteria and...
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Simple sensitive and accurate spectrophotometric methods have been developed for the estimation of ambroxol hydrochloride in pharmaceutical dosage form. The drug was diazotised with sodium nitrite in presence of acetic acid and then it was coupled with catechol or resorcinol or β-naphthol in alkaline medium. The resulting coloured chromogenic species in solution were directly measured at their ...
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This paper deals with multiple response simultaneous optimization using the Derringer’s desirability function for the development of a reversed-phase HPLC methods for the simultaneous determination of Ambroxol(AMB) and Montelukast(MLS) with Levocetirizine (LCT) in commercial pharmaceutical preparations with Probenecid(PRO) as Internal standard. The ranges of the independent variables used for t...
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Chemometrics-assisted UV spectrophotometric and RP-HPLC methods are presented for the simultaneous determination of tolperisone hydrochloride (TOL) and diclofenac sodium (DIC) from their combined pharmaceutical dosage form. Chemometric methods are based on principal component regression and partial least-square regression models. Two sets of standard mixtures, calibration sets, and validation s...
متن کاملSimultaneous Determination of Doxylamine Succinate, Pyridoxine Hydrochloride and Folic Acid by Chemometric Spectrophotometry
Simultaneous estimation of three component tablets containing Doxylamine succinate (DOX), Pyridoxine hydrochloride (PYR) and Folic acid (FA) was carried out by UV spectrophotometric assisted chemometric methods. Four chemometric methods i.e. classical least square (CLS), inverse least square (ILS), principal component regression (PCR) and partial least squares (PLS) were applied to simultaneous...
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ژورنال
عنوان ژورنال: Journal of Chemical Metrology
سال: 2020
ISSN: 1307-6183
DOI: 10.25135/jcm.47.20.05.1638